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Life Extension, DHEA - 25 mg, 100 tablet
(LEF-00607)


Life Extension, DHEA - 25 mg, 100 tablet
    
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DHEA
25 mg, To be Dissolved in Mouth Before Swallowing 100 tablets
Item Catalog Number:
607

In 1981, the Life Extension Foundation introduced DHEA (dehydroepiandrosterone) to its members through an article that described the multiple benefits that this hormone might produce. However, the general public did not learn about DHEA until 1996, when the benefits of DHEA were touted by the news media and in several popular books.

DHEA became credible to the medical establishment when the New York Academy of Sciences published a book entitled DHEA and Aging. This book provided scientific validation for the many life extension effects of DHEA.

It has been shown that the hormone DHEA often declines 80-90% by age 70 or later, leading to hormonal imbalances that can affect one’s quality of life. Peak blood levels of DHEA occur at approximately age 25, decreasing progressively thereafter. Thus, scientists have been looking at ways of restoring DHEA to youthful levels, and are now discovering mechanisms by which this hormone protects against age-related decline.

Since 1981, thousands of studies have been published on DHEA’s possible benefits. One study investigated immune functions and DHEA using rats as test subjects. The scientists showed that DHEA administration to rats supports specific immune function known to be lacking in the elderly.1*

Another study focused on the various benefits of DHEA supplementation, and noted that DHEA’s protective effect could be of benefit to the normal aging brain.2 Some studies have reported DHEA may improve mood and alleviate melancholy. In fact, as highlighted in two studies, participants have reported that they feel better when taking DHEA.3-4*

In still another investigative study doctors noted that DHEA is one factor that determines lumbar spine density in aging men.5 In women, it has been shown that DHEA helps to protect bone mineral density. DHEA’s role in supporting a healthy circulatory system and joint/bone health was also highlighted in the Journal of the Medical Association of Thailand.6*

The Life Extension Buyers Club DHEA supplement conforms to the following specifications:

  • 99.9% purity (European-derived DHEA)
  • Micronized (for maximum absorption and utilization)
  • Manufactured under GMP (Good Manufacturing Practice) conditions

DHEA dosing and safety precautions
The Life Extension Foundation has been investigating DHEA for more than 20 years. Life Extension’s DHEA directions for use are specially drafted to provide optimal, but safe dosing.

A DHEA-S (dehydroepiandrosterone sulfate) blood test may be taken three to six weeks after initiating DHEA supplementation regimen to help determine optimal dosing. When having your blood tested for DHEA, blood should be drawn three to four hours after the last dose. DHEA testing may save you money if it shows that you can take less DHEA to maintain youthful DHEA serum levels.

The standard blood test to evaluate DHEA status is one that measures DHEA-S. The DHEAS is calculated in micrograms per deciliter (mcg/dL) of blood.

The youthful ranges of DHEA are as follows (mcg/dL):

Men

400-560

Women

350-430

People over age 40, who do not supplement with DHEA, usually have serum levels below 200, and many are below 100.

Some people obtain a baseline DHEA-S blood test before beginning DHEA supplementation. However, based upon numerous DHEA blood tests evaluated by the Life Extension Foundation, anyone over 40 who does not supplement with DHEA is already deficient in serum DHEA.* Therefore it may be more economical to have the first DHEA blood test three to six weeks after initiating DHEA. There are precautions that should be observed that are different for men and women.

Men
Before attempting to restore DHEA to youthful levels, men should know their serum PSA (prostate specific antigen) level and have passed a digital rectal exam. Men with prostate cancer or severe benign prostate disease are advised to avoid DHEA since it can be converted into testosterone (and estrogen). Therefore, men are advised to have a PSA and digital rectal exam before initiating DHEA to rule out existing prostate disease.

When taking DHEA we also recommend taking the following other nutrients:

Vitamin E

400-800 IU daily

Selenium

200 mcg daily

Mega Soy Extract
 ,  , (40% isoflavone extract)

135 mcg twice daily

Lycopene Extract

20-30 mg daily

Saw Palmetto Extract

160 mg twice daily

Pygeum Extract

50 mg twice daily

Nettle Extract

120 mg twice daily

Gamma tocopherol

200 mg daily

Boron

3-10 mg daily

It is important for men over 40 to consult their physician to check their PSA and DHEA-S serum levels every six to twelve months thereafter. Men should also periodically check their blood levels for free testosterone and estrogen to make sure that DHEA is following a youthful metabolic pathway. See the Male Hormone Modulation chapter in the Disease Prevention and Treatment book for additional hormone balance testing that can be done at the same time serum DHEA and PSA levels are being tested.

Women
When taking DHEA we also recommend taking the following other nutrients to maintain a healthy balance.

Melatonin

300 mcg to 3 mg nightly

Vitamin E Succinate

400-800 IU daily

Mega Soy Extract
 ,  , (40% isoflavone extract)

135 mg twice daily

Indole-3-carbinol

200 mg two to four times daily

Vitamin D3

1000-1400 IU daily

Gamma tocopherol

200 mg daily

Women should consider estrogen and testosterone testing when they take their DHEA blood test in order to evaluate DHEA’s effect on their blood levels of these hormones.

Women who have been diagnosed with an estrogen-dependent cancer should consult their physicians before beginning the DHEA restoration process. Women taking DHEA should refer to the Female Hormone Modulation chapter in the Foundation’s Disease Prevention and Treatment book for information about restoring youthful hormone balance.

References
1. J. Immunol. 2002 Feb 15, 168(4):1753-8
2. J. Endocrinol. Invest. 2002 Jan, 25(1):73-83
3. J. Clin. Endocrinol. Metab. 2000 Dec, 85(12):4650-6
4. Biol. Psychiatry . 1999 Jun 15, 45(12):1533-41
5. Calcif. Tissue Int. 2002 Mar, 70(3):137-45
6. J. Med. Assoc. Thai. 2001 Oct, 84 Suppl 2:S605-12

Many seeking to restore their DHEA levels to a youthful state take 15 mg to 75 mg of this hormone per day. However, the fact that DHEA capsules are metabolized in the liver before being released into the bloodstream is cause for concern among some people, especially those with liver disease.

Life Extension Buyers Club has formulated a DHEA lozenge that should be dissolved in the mouth before swallowing for those individuals with liver impairment who do not wish to put added stress on the liver. Micronized for optimal assimilation, this 25 mg DHEA lozenge should be held in the mouth and then swallowed.

Supplement Facts

Serving Size 1 tablet

Servings Per Container 100

Amount Per Serving

Dehydroepiandrosterone (DHEA)

25 mg

Other ingredients: microcrystalline cellulose, cross-linked povidone, stearic acid, colloidal silica, gelatin and water.

Dosage and Use
-

For optimal results, take one to three tablets in the morning only.

-

DHEA serum blood tests are suggested 3 to 6 weeks after initiating DHEA replacement therapy to optimize individual dosing.

-

Do not take in the evening as it could interfere with sleep.

-

Refer to Life Extension Foundation’s DHEA precautions or the DHEA Replacement Therapy chapter in the Disease Prevention and Treatment book before taking this product.

DHEA Precautions

DHEA can be converted into testosterone (and estrogen). These sex hormones and their metabolites have been associated with the maintenance of a healthy prostate. Men with prostate cancer or severe benign prostate hypertrophy are advised to avoid DHEA. Women with estrogen-dependent cancer should consult their physicians before using DHEA products.

Caution

If you have liver impairment or are currently being treated for liver related disease, consult your physician before using this product.

Warnings
-

Keep out of reach of children.

-

Do not exceed recommended dose.

-

Do not purchase if outer seal is broken or damaged.

- If you have a bad reaction to product discontinue use immediately.
-

When using nutritional supplements, please inform your physician if your are undergoing treatment for a medical condition or if you are pregnant or lactating.


Import Restrictions: Canada, Guadeloupe, Japan, Monaco, Austria, Singapore, United Kingdom



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