Health conscious people have been consuming a lot of borage oil to obtain GLA (gamma-linolenic acid), the parent of the biologically active DGLA (di-homo-gamma-linolenic acid). Life Extension has added 10 milligrams of sesame lignans to each capsule of Mega GLA borage oil. Sesame lignans not only increase beneficial DGLA, but they also help control pro-inflammatory arachidonic acid, which decreases the formation of destructive prostaglandin E2 and leukotriene B4.1
Numerous studies document GLA’s multiple health effects, but new information about the ability of sesame to prevent the conversion of GLA into arachidonic acid indicates that many more people may now be able to benefit from supplemental GLA.2
1 Chavali SR, Zhong WW, Forse RA. Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL6, IL-10 in response to LPS: effects of sesamin on the delta-5-desaturatoin of omega-6 and omega-3 fatty acids in mice. Prostaglandins Leukot Essent Fatty Acids. 1998 Mar,58(3):185-91.
2. Umeda-Sawada R, Fujiware Y, Abe H, Seyama Y, Effects of sesamin and capsaicin on the mRNA expressions of delta-6- desaturases and delta-5-desaturases in rat primary cultured hepatocytes. J Nutri Sci Vitaminol (Tokyo). 2003 Dec;49(6):442-6.
Serving Size 1 softgel
Servings Per Container 60
|Amount Per Serving|
Calories from fat
Borage seed oil (Borago officinalis) gamma-linolenic acid (GLA) 285 mg
Sesame seed (Sesamum indicum) lignan extract [standardized to 60% sesamin (6 mg)]
Other ingredients: magnesium stearate, gelatin and water.
The borage oil in Mega GLA is cold pressed, and is free of any pesticides and herbicides. This is a natural product and the amount of GLA can vary, but is never less than 285 mg per capsule.*