mg, 30 enteric coated tablets
helps maintain stable mood and joint
function without side effects. In addition, SAMe has multiple
action that are used throughout the body, especially in the liver,
maintain liver health. Largely known for its effects on optimal mood,
also shown benefits for the liver, brain, and joints.
at a glance:
maintain stable mood
maintain liver health
maintain healthy joint function
Extension® first introduced SAMe
(S-Adenosyl-Methionine) in 1997, and researchers continue to discover
impressive benefits of this versatile nutrient.
is an amino acid derivative normally
synthesized in the body that may become depleted with sickness or age.
Supplementing with SAMe plus folate, trimethylglycine (TMG or betaine),
vitamins B6 and B12 appears to be an effective way to overcome this
is concentrated in the liver and brain
and is a major methyl donor in the synthesis of hormones, nucleic
proteins, and phospholipids, and catecholamines and other
SAMe is required for the synthesis of norepinephrine, dopamine, and
SAMe facilitates glutathione usage, which improves the body's
defense. It also helps maintain acetylcholine levels which are
is used by the body in three important
(contributing methyl groups to
activate certain molecules)
synthesis of polyamines (for cell growth,
gene expression, neuronal regeneration, etc.)
(synthesis of cysteine,
glutathione, and other sulfate chemicals)
2002, an agency of the U.S. Department of
Health and Human Services conducted a meticulous evaluation of SAMe.
findings show the efficacy of SAMe in helping to maintain stable mood
function without any side effects. Since aging people often suffer
and immobilization, SAMe addresses multiple problems people face as
has multimodal mechanisms of action that
are used throughout the body and especially in the liver. In order to
its detoxification role, the liver continually performs large numbers
complex enzymatic reactions. SAMe facilitates healthy methylation
processes and boosts hepatic levels of glutathione, a critical
When liver function is compromised, glutathione is depleted, which
free radical damage. In addition, SAMe acts as a methyl donor in the
and formation of phosphatidylcholine and L-cysteine, both necessary for
maintaining liver health.
recent study conducted at Harvard Medical
School and Massachusetts General Hospital cited the benefits of SAMe
elevation. In addition, a report published in Germany indicates that
help maintain healthy neurological function. The report revealed that:
increased glutathionelevels by 50% and
glutathione enzyme activity by 115%.
decreased a measurement of free radical
activity by 46%.
inhibited lipid peroxidation by 55% in
ability to boost brain cell
methylation facilitates youthful DNA enzymatic actions which may help
for SAMe’s mood-elevating properties. These enzymatic reactions are
for the healthy conversion of neurotransmitters such as serotonin and
1 enteric coated tablet
ingredients: cellulose, mannitol, hydroxypropyl methylcellulose
phthalate, citric acid, stearic acid, silica, glyceryl triacetate,
sodium starch glycolate, croscarmellose sodium, titanium dioxide,
one (1) tablet one to three times daily in divided doses, preferably on
an empty stomach, or as recommended by a healthcare practitioner.
with co-factors vitamins B12, B6, and folic acid.
should not be taken by those diagnosed with bipolar disorder.
OUT OF REACH OF CHILDREN
NOT EXCEED RECOMMENDED DOSE
not purchase if outer seal is broken or damaged.
using nutritional supplements, please consult with your physician if
you are undergoing treatment for a medical condition or if you are
pregnant or lactating.