a fat-soluble form of vitamin B1 (thiamine), supports healthy blood
sugar metabolism and helps protect the body’s tissues against advanced
glycation end products and oxidative stress.For example, the enzyme
transketolase is critical to blood sugar metabolism. Like many enzymes,
transketolase requires a co-factor. In this case, it needs assistance
from thiamine. Unfortunately, thiamine is water-soluble, which makes it
less available to the interior of the cell. Benfotiamine is fat-soluble
and can easily penetrate into the inside of cells. It is also more
bioavailable than the water-soluble thiamine.
a landmark study, benfotiamine effectively increased transketolase
activity in cell cultures by an astounding 300%, compared to a mere 20%
for thiamine. This robust activation was sufficient to block three of
the four major metabolic pathways leading to blood vessel damage.Benfotiamine also blocks the
activation of the transcription factor known as nuclear factor-kappa B
(NF-kB), which is implicated in numerous inflammatory conditions.
benfotiamine can activate glucose metabolism and promote healthy blood
glucose levels in those already within normal range. Benfotiamine also
helps maintain healthy endothelial functionand supports the health of the
nerves, kidneys, eyes, blood vessels, and heart.
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